[VanBUG] Thurs, Mar 8, 6pm – Nathan Price, ISB – Integrated modeling of metabolic and regulatory networks‏

Please post poster available at http://vanbug.org
Next VanBUG (Vancouver Bioinformatics User Group) talk is on Thursday,
March 8 at 6pm. The seminar is followed by pizza, refreshments and great

*Intro speaker* (10mins): Evan Morien, MSc candidate, Pavlidis lab,
Title: Genomic Expression Patterns in Wild Pacific Salmon

*Featured speaker*: Nathan Price, Associate Professor, Institute for
Systems Biology, Seattle, WA

Title: Integrated modeling of metabolic and regulatory networks

To harness the power of genomics, it is essential to link genotype to
phenotype through the construction of quantitative systems models. I
will discuss approaches for the creation of such quantitative models
that can simulate a variety of cellular functions. I will focus
particularly on automated methods for integrating metabolic and
regulatory networks such as our newly developed approach, Probabilistic
Regulation of Metabolism (PROM) (Chandrasekaran and Price, PNAS, 2010).
PROM is notable in that it represents the successful integration of a
top-down reconstructed, statistically inferred regulatory network with a
bottom-up reconstructed, biochemically detailed metabolic network,
bridging two important classes of systems biology models that are rarely
combined quantitatively. Additionally, I will discuss our new strategy
to curate the inference of regulatory interactions from high throughput
data using metabolic networks—providing multiple layers of biological
context to the problem of regulation. Finally, I will describe our
approach to building tissue and cell type specific metabolic models,
which we have now done for 131 different cell types and tissues in the
human body.

Please note:
Students and postdocs are invited to meet with the VanBUG speaker for
open discussion of both science and career paths. This takes place
4:30-5:30pm in either the Boardroom or Lunchroom on the ground floor of

Recommended Reading:
Modeling of genome-scale metabolic and regulatory networks

675 West 10th Avenue
Gordon and Leslie Diamond Family Theatre
BC Cancer Agency

Start Date: 08/03/2012
Start Time: 6:00 PM
End Time: 7:30 PM

Contact Name:
Stefanie Butland

The VanBUG team:
Stefanie Butland
Cedric Chauve
Bhavjinder Dhillon
Rodrigo Goya
Elodie Portales-Casamar

VanBUG is generously sponsored by the CIHR Bioinformatics Training
Program, MITACS, PIMS, GenomeBC, and the Canadian Bioinformatics Workshops

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